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PESNCIPE ARSTRACTS 4

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81-1414. Torok, G.; Borzsonyi, M.; Pinter, A.; Surgen,
As, Nadasdi, L. (Natl. Inst. Public Health, Budapest,

Hungary) Peszticidbol keletkezett dinitrozopiperazin kar-
cinogen hatasanak vizsgalata felnott Swiss egerekben es
transzmateratis expozicio utan. {Study of the carcinogenic

effect of dinitrosopiperazine formed from a pesticide in

IZ.

adult Swiss mice and following fetal exposure.} Afag.
Onkol. 24(4): 265-272; 1980 (30 references) (Hungarian).

The carcinogenic effect of | 4-dinitrosopiperazine,
a metabolite of the fungicide triforine, was studied in
random-bred Swiss mice. The carcinogen was administered
in drinking-water (100 mg/l) given ed libitum. Group A (50
males and 29 females) served as untreated controls. Group
B (22 adult males and 14 adult females) were treated for 1
yr. Group C (12 males and 13 females) were exposed to tlic
carcinogen transplancentally by treatment of their mothers
between days 15-21 of pregnancy. Group D (9 males and
11 females} were exposed to the carcinogen during lactation
by treatment of their mothers during this period. The ex-
periment lasted 702 days. The mean survival was 397.3
days in group A, 254.2 days in group B (p < 0.01), 360.6
days in group C, and 355.8 days in group D. The percen-/
tages of tumor-bearing animals were 55.7% (38% for
males and 86.2% for females) in group A, 69.4% (68.2%
for males and 71.4% for females) in group B, 92% (91.7%
for males and 92.3% for females) in group C {p < 0.01),
and 93.3% {100% for males and 81.8% for females) in
group D (p < 0.01). The mean latent period was 369.7 days
in group A, 268.5 days in group B (< 0.01), 353.0 days in
group C, and 366.0 days in group D. The percentage of
lymphoma and leukemia was 32.9% in group A, 36.1% in
group B, 64% in group C, and 40% in group D. The
percentage of pulmonary adenoma was !2.7% in group A,
38.9% in group B, 28% in group C, and 63.3% in group D.
Hepatoma was found in 7.6%, 8.3%. 12% and 53.3% of
the animals in group A, B, C and_D, respectively. Breast
cancer,was found in 7.6% of the females in group A and in
2.8% of the females in group B. Papilloma of the
forestomach was found in 5.6% of the males in group B, in
4% of the males in group C, and 3.3% of the males in
group D. The findings show that exposure of pregnant and
lactating mothers to carcinogens may result in increased
tumor incidence in the offspring.

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69, POLICY AND REGULATORY ASPECTS OF N-NITROSO CONTAMINANTS IN PESTICIDE PRODUCTS.
. Gunter Zvetg and Willa Garner, School of Public Wealth: Univ. of Caltfornia,
Berkeley, CA 94720 and EPA, Office of Pesticide Frograms, Washington, B.C. 20460

Several pesticides tuve been found to contatn detectable levels of '-n{troso con-
taminants, like dipropylnitraseaine and dinethyl-nitrosamine. Both of these nitrosanines
and others are known carcinogens in experlaental animals. For this reason, EPA had {ni-
tiated during 1976-1977 an Agency-industry program to analyze several hundred repr rt
ative pesticide products which were belfeved to be likely candidates for N-nitroso cua-
tamtnation, Results of these analyses were published (Bontenyan, etal ric. Food
Chem. 1979, 27, 631-635; and Zugtg, et al., Analytical Survey of S-Hitroso Contaminants

“Whesitele Products, to be publ fghed in Proceedings, Internat tonal Agency for Research
ou Cancer, Hudapest, Qungary . 1229). EPA Is wow proposing a policy (FR, 45, 126,
or

5
“GI8SC=47358, June 25, 1980) dealing with a) analytical requlrerenta f. =attroso analy-
s )

fe, b) assessment of risk, and c) recommendations for reduction or elimination of H~
nitroso-cuntaaination. The final Published polfcy will be discussed and bachyiound
inforration furnished on the rattonate of the policy. Pubic coments recetved by EPA
alter publication of proposed policy and thele resolution ulli be discussed.

Pesticide makers try to get rid of nitrosamines
Pesticide makers are engaged ina major effort to eliminate
nitrosamines from pesticide formulations, says Gerald W.
Probst of Lilly Research Laboratories. Nitrosamines can be
formed by action of nitrosating agents on secondary amines
during manufacture, or by use of nitrite or nitrate to inhibit
container corrosion. Formation can be minimized by re-
moving nitrosating agents from raw materials and inter-
mediate nitration products by aeration and scrubbing. Trace
nitrosamines in finished products can be destroyed most
effectively by treatment with hydrochloric or hydrobromic
acid, or by use of aliphatic ketones and aldehydes in the
presence of a strong acid. But sometimes, Probst says, total
elimination can't be achieved. (For more on nitrosamines,
see page 30.)

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