<perimanital evidence of carcinogenic and other relevant biological effects of N-nitrasatable

ugs

No review of such evidence will be attempted; however, references th the relevant

idies are summarized in Tables 4, 5, 6 and 7.

Table 4. References to carcinogenicity tests on N-nitrosatabie drugs adminisinred
in conjunction with sodium nitrite

Table 5. Raferences to carcinogenicity tests on nitrosation products of V-nitrosstable drugs

a6

air i ole Wie

4

:

",:Nivesation product

Mice

Rats

Drug

Mice

Rata

Aminophenazone

Chlordiazepoxide
Disulfiram
Ephedrine hydrochloride

Ethambutol

Lucanthone hydro-
chloride

Methapyritene

Methapyrilene hydro-
chloride

Oxytetracycline hydro- ©

chloride

Piperazine

Propylhaxedrine hy-
Grochloride

Alexandrov & Napatkov (1979)
{prenatal exposure}

Biancifiorl et a/. (1975)

Greenblatt et af. (1971):
Greenblatt & Mirvish (1972)

Lifinsky et af, {1973}; Taylor
& Liflosky (1975); Chan
& Fong (1977); Scheunig
et ai, (1979)

Alexandrov & Napalkov corel
ipranatal exposure) =:

Lifinsky & Taylor (19772,b)

” W-Nitrosoephedrine

' N-Nitrosopiperazina

-.N,WDinitrosopiperazing

N-Nitrosophenmetrazine

N-Nitvosophenidate

Wonen et a/. (1975) {i.p. injections)

Greenblatt & Mirvish {1972}

Zabezhinsky (1969); Greenblatt
etal. (1971)

Schmiht & Thomas (1965);

> Zabezhinsky (1969) (s.c. admini.

stration)

Eisenbrand et af. (1978)

Garcia et af. (1970):
Love et al. (1977)

Druckrey et af. (1967);
Druckrey et a/. (1964,
1967) (s.c, administra-
tion); Weisburgar et af.
(1966); Hadidian e¢ af,
(1968); Garcia &
LiJinsky (1972}:
Lijinsky & Taylor
(1975)

LiJinsky & Taytor (1976)

Lifinsky & Taylor (1976)

Lijinsky & Rauber 11980)

Schneider er al. (1977)

Lijinsky & Taylor (1977a,b)

Tebte 8, Roferences to mutaganicity and other, related short-term tents

on N-nitrosateble drugs

Lijinsky & Taylor (19778,b}

Compound

Mutagenicity

v
Chromoromal
aberrations

Frederick Cancer Research
Center {1979}

Taylor & Lifinsky (1975)

Garcia & Lijinsky (1973);
Schneider et ai, (1977)

Schneider et af. (1877)
(prenatal exposure)

Schneider et a/, (1977}

Aminophenazone

+ sodium nitrite

+ nitrite

+ scdium nitrite

Arisawa et af, (1978)
{S. typhimurium)

Blijleven (1979)
(Drosophita)}

Inul et sf, (1978)
(hamster embryo cells)

Newton & Lilly { 1977)
(rat lymphocytes)

Test compounds were administered by the oral route, unless otherwise specified.