CHLOROTHALONIL Trade names: Bravo, Daconil Acute effects: S : Oral LD50: >10,000 mg/kg (active ingredi- ent, Daconil); 4,200 mg/kg (Bravo 500) Dermal LD50: >10,000 mg/kg (active ingre- dient, Daconil, Bravo) LC50: 0.31 met eye ea mg/L (Bravo 500); 0.54 mg/L (Daconi 7 eins nd Sensitization: it is a con- tact allergen, slight skin irritant, moderate eye irritant. There are documented reports of workers developing a skin rash when contam- inated skin was exposed to the sun. Breathing the vapour may cause throat and lung irrita- tion Chronic Pate a no effects in 2 peat geet ing trial to rats at 60 mg/kg diet or in dogs fe 12) me/kg Mutagenicity: negative in all tests to date Carcinogenicity: limited evidence that it is a carcinogen in animals — rats and mice fed 97% chlorothalonil at high levels in the diet develop kidney tumors. But the mechanism is understood and a NOEL (no-observable- effect-level) can be established. No informa- tion is available to evaluate carcinogenicity in humans but the mechanism for development in rats and mice cannot be duplicated in humans Effects on Reproduction: reproduction Studies in rats have shown a metabolite that is released into mothers’ milk depresses the rate of growth of their offspring. The effect was reversed upon weaning. Women who are breast feeding should not work with chlorothalonil DDAC Trade names: Bardac 22, Bardac 2280. Combined with IPBC in the following: NP-1, Chapco SA-1, Timbercote 2000. Combined with borax in F-2 Use: anti-sapstain, disinfectant/sanitizer in hospitals and institutions, mildew preventa- tive for commercial laundries Acute effects: Oral LD50: 450 mg/kg (Bardac 2250/2280) Dermal LD50: 4300 mg/L (Bardac 2250/2280) LC50: no information available Irritation and Sensitization: extreme eye irritant and severe skin irritation Chronic effects: Mutagenicity: negative in all studies to date Carcinogenicity: studies in progress Effects on Reproduction: studies in progress — negative in all studies to date COPPER-8-QUINOLATE . Trade names: Nytek GD, PQ-57, Mitro PQ- Acute effects: at concentrations of less than 700 mg/kg, no harmful effects of any kind were observed in test animals Oral LD50: — 2 — rat); 5900 2 (female rat); >! mg/kg (Nytek GI | matic ais _— $2,000 mg/kg; >5000 mg/kg iyte! LC50: 0.82 mg/L; 140 mg/m" Irritation and Sensitization: prolonged contact may cause severe skin irritation depending upon the product. Permanent eye damage is reported for Mitrol PQ-8. Not a skin sensitizer. Excessive breathing of vapours from Mitrol PQ-8 can cause nose and throat irritation, dizziness, weakness, fatigue, nau- sea, headache, and possible unconsciousness and death Chronic effects: at the highest doses test- ed all the test animals were listless and had diarrhea. All those that survived the test recovered fully within 7 days Mutagenicity: mixed results, further test- ing underway Carcinogenicity: no information available Effects on Reproduction: negative in all studies to date IPBC Trade names: Sta-Brite A, Sta-Brite P, Troysan Polyphase P-100, Troysan Polyphase AF-1, Woodgard E.C. Acute effects: can be absorbed through the skin Oral LD50: 1795 mg/kg (male rat); 249 mg/kg (Sta-Brite P, female rat); 779 mg/kg (Sta-Brite P, male rat); 1050 mg/kg (female rat) Dermal LD50: >2000 mg/kg LC50: 1.1025 mg/L Irritation and Sensitization: severe eye and skin irritation. Not a sensitizer Chronic effects: Mutagenicity: negative in all studies to date Carcinogenicity: studies in progress Effects on Reproduction: in a study of 2 generations of rats a slight increase in the number of stillborn pups was seen in both generations at the highest dose tested (750 ppm) TCMTB Trade names: Busan 1030, Busan 30WB Use: fungicide, microbicide on/in fresh- sawn lumber, leather, caulking-sealants, vinyl acetate wallcovering adhesives, cutting fluids and paints Acute effects: Oral LD50: 556 mg/kg (male rat); 702 mg/kg (female rat); 1,200 mg/kg Dermal LD50: >2500 mg/kg (rats) LC50: >0.17 mg/L (60% active ingredient) Irritation and Sensitization: corrosive to eyes and skin. Strong skin sensitizer Chronic effects: only inflammation of the stomach lining was seen in rats fed up to 750 ppm or in dogs fed 500 ppm Mutagenicity: all tests to date negative Carcinogenicity: all tests to date negative Effects on Reproduction: only inflamma- tion of the stomach lilning but there were no birth defects at levels up to 125.5 mg/kg in rats and 40 mg/kg in rabbits © On the gre Kwong Nang uses prot hain terfor’s MacKenzie Seizai division in Surrey, B.C. Local 1-357 member Cho Obek are mere and apron while off-bearing lumber treated with anti-sapstain chemi- ° Brother Davis applies tape to seal coverall and glove connection. A protective skin barrier cream is also applied to hands, face, and open skin areas. Since the last column was completed I have received more information from the manufacturers of glyphosate and chlorothalonil. The new glyphosate box is below and chlorothalonil is included in the anti-sapstain boxes. GLYPHOSATE Trade names: Roundup, Vision Use: broad-spectrum, non-residual herbi- cide Acute effects: Oral LD50: 5400 mg/kg (rat) Dermal LD50: 7940 mg/kg LC50: (12.2 mg/L air (4 hour) Irritation and Sensitization: the undilut- ed concentrate has caused severe eye and mild skin irritation. There are documented reports of workers developing a skin rash when contaminated skin was exposed to the sun. These workers only had a reaction when the contaminated skin was exposed to the sun. In response the manufacturer tested a 10% solution on 346 volunteers and found it was less irritating than dish washing deter- gent, didn’t cause sensitization, or have the potential for photo irritation or photo sensiti- zation (the fancy terms for a rash caused by sunlight on contaminated skin). The manufac- turer has stated that the rashes caused by glyphosate-containing products are not due to the glyphosate itself but to an “inactive” ingre- dient that acts as a surfactant. Researchers have looked at exposure in workers at an Arkansas conifer seedling nursery. Cotton gauze patches were attached to worker cloth- ing during normal work sessions. The highest levels were found on the ankles and thighs. Urine was collected for 12 weeks after expo- sure and urine analysis did not show any glyphosate in any samples. This suggests that little or no glyphosate “got inside” any of the workers Chronic effects: in long-term feeding stud- ies in mice and rats there were no signs of toxicity at any dose level Mutagenicity: no evidence from any study Carcinogenicity: no evidence from any study. The US Environmental Protection Agency has placed glyphosate in Category E — no evidence of carcinogenicity based on ade- ae evidence (this is the best possible rat- ing Effects on Reproduction: no effect in rabbit, monkey, dog or rats For the complete series of Lumber- worker articles written by Shona Kelly on the safe use of pesticides in the workplace contact: Editor, IWA-CANADA Lumberworker 500-1285 West Pender Street Vancouver, B.C. V6E 4B2 LUMBERWORKER/OCTOBER, 1992/11