art III in a series by Shona Kelley Research Seferusy Jniversity In thi jays pd tral (enetttello. JPET LIpoY? h Pe . To do thi we should review a few Borns. is here are 2 ways for pesticides to affect u: ) Internally — these are the effects usually associated sas foe ore poisoning. Effects like matitis é skin rash). Second, we have developed measures of acute (immediate) vs chronic (long-term) effects. We measure acute effects with the ee or the ‘dose sex, age, 50% of a population of test animals exposed to the pestic ir. We chronic effects in several w b) Teratogenesis — does it ees birth distets 12 in developi: ing fe fetus th rep! roductive cells who are eee onto fubute generations This can also be assessed with bac: or cells in “test tubes” effect: (males and females) Now lets talk about the specific pesticides you use. We'll start with the ones q, have the least information on and work up to the ones for which there is more informa’ tion Before you panic about the chronic effects information on some of the pesticides I would | like to remind you of a few things. First, your body was designed to combat outside “attack” from foreign cubsteness cteria and chemicals. Your liver very } 7 b t restrict remember a Tree nursery workers must be — aware of effects of chemicals — above, al substances are toxic to humans and that is why the liver is so effective. Third, most of the carcinogenicity studies on lab animals involve eating pesticides mixed in with their food. if you follow Sood working practices you won't eat any of these pesticides. Just to remind you, good Sore practices include: - Wear protective clothing like gloves - Wash) pesticide contaminated clothing e your lunch where it ¢: become RTA with sprays oa residues PTAN Year introduced: 1949 Use: fungicide Acute effects: CAN BE ABSORBED THROUGH THE SKIN Oral LD50: 9000 mg/kg. Dermal LD50: no information available LC50: no information available WCB personal exposure limit: 5 mg/m. Irritation and Sensitization: it isa hi. 3 an 1 outside ans see they can caper contaminat- ok t washing yo ha: aac Malteogns frankly, uae have a eee greater risk of developing cancer from cigarettes ° wae eye xnpbered gloves sre. 9 oe recom- ended during the seedling lifting p! For some of these pesticides manufacturing orkers, who are exposed to much, much higher ea Baal for longer periods of time, have been studied. They have not thee found to have. igh- ae onic effects: was still detectable on on the hands of a firme who wore gloves. 10,000 ppm in feed for 54 ks cause growth retardation in rats. Severe protein deficiency coun aot sed suscep ane to toxic effects | Mutagenicity Paithecdtt in most test systems but no changes to the eee er levels of cancer than limited evidence ae mation tha into not using eaaiatlss, But ne to reinforce net at Should be used with care and not taken for ear the next and final column I will discuss ihe pesticides used for antisapstain control i BENZALKONIUM LORIDE Trade name: Roccal Use: It rr as annual in pete No aS aay avaueple to evaluate pe iais, to Bffects on reproduction: non This is one of the few pesticidesd in which the efieetiveneud s&s laundering has been studied. Only 72% of ca) ee! 2B ser from denim when the was! as 38°C ut 98% was removed mee sean! “wvash- mais was 49°C. For Gor-Tex or Tyvek fab- ate 99% was removed at either temper- has been used tion for asthmatics, in nasal sprays and contact lens solutions. There are a large jumber of benzalkonium. chlorides but the aes effects: Oral LD50: 445 rmal LD50: no information available Tes: no information available WCB personal exposure limit: mone Irritation and sensitization: contact allergen, mild | to caalerata Aaa irritation, moderate eye irritation Chronic effects: Mutagenicity: no information available Carcinogenicity: no information ayail- able Effects on reproduction: no informa- tion available TEBUTHIURON qeade name: Spike eam spectrum herbicide ise: broad S| Oral LD50: 644 Dermal LD50: 286 mg/kg. nae no information available 6/LUMBERWORKER/AUGUST, 1992