We w28 Wisse sxveunveveocorm Monsanta COMMERCIAL ‘Water soluble herbicide for silvicultural sites REGISTRATION NO. 19899 PEST CONTROL CAUTION IRRITANT PRODUCTS ACT @ GUARANTEE: Glyphosate 356 g/L present as isopropy- lamine salt READ THE LABEL BEFORE USING. & 1992 89710-00423 (FRANGAIS AU VERSO) AVOID CONTACT WITH FOLIAGE, GREEN STEMS, OR FRUIT OF NON- TARGET CROPS, DESIRABLE PLANTS. AND TREES, SINCE DAMAGE TO. THESE PLANTS MAY RESULT. PRECAUTION! Keep out of reach of children. MAY CAUSE EYE IRRITATION. HARMFUL IF SWALLOWED. Avoid contact with eyes or prolonged contact with skin. FIRST AID: if in eyes, immediately flush eyes with plenty of water for at least 15 minutes. Calla physi- cian. If on skin, immediately flush with plenty of water. Remove contaminated clothing. Wash clath- ing before re-use. If swallowed, this product will cause gastrointestinal irritation. Immediately dilute by swallowing water or mk. Call a physician Read NOTICE before buying or using. If noticé terms are not acceptable, return at once unopened. Canadian Patent 936,865 Not for reformulation or repackaging “*Registered trademark of Monsanto Company, USA ‘Monsanto Canada Inc. registered user MONSANTO COMPANY 1992, MONSANTO CANADA, INC. Streetsville, P.O. Box 787 Mississauga, Ontario LEM 264 St.John « Montreal « Thunder Bay « Winnipeg * Vancouver IN CASE OF EMERGENCY INVOLVING THIS PRODUCT, Call Monsanto Collect, day or night 7 Accidents/Spil... _.(514) 966-5588 Medical Emergency (314) 694-4000 or CANUTE... (613) 996-6666 product (not each active ingredi- ent) has a unique PCP Number. If you haven't time to grab anything else in an emergency situation, get the PCP Number! READING AN MSDS A label from a pesticide is a good place to start collecting information, but if more details are needed you should obtain an application sum- mary and an MSDS. Pesticides are <= not covered under WHMIS and so the Material Safety Data Sheets may not be exactly the same as the others you have for other chemicals. In this arti- cle I have included sections of the MSDS for Vision Herbicide. (Below) . Product Identification — includes a list of active and inert ingredi- ents, the PCP Number and Trans- portation of Dangerous Goods (TDG) information. . Warning Statements, Precaution- ary Measures, Emergency and First Aid Procedures — similar to those found on the label. . Occupational Control Procedures — this is detailed information on protective equipment. It specifies the type of protective equipment that should be worn when you are applying the pesticide. There is enough information here for a safety supply company to provide you with the correct equipment. Monsanto materiat SAFETY DATA MONSANTO CANADA ING. 2330 ARGENTIA RD. MISSISSAUGA, ONTARIO L5M 2G4 Active Ingredient:* 38641-94-0 19899 None EMERGENCY PHONE NUMBERS — MONSANTO PRODUCT NAME RCA GOLLEC Monsanto Canada inc. ...+..+e++e++ (514) 366-5588 (Accidents) VISION® HERBICIDE MonsantoUSA (314) 694-4000 (Medical Emergencics} ‘CANUTEC +++ (613) 996-6666 ‘See page 6 for additional information PRODUCT IDENTIFICATION ‘Synonyms: None Chemical Name: Not Applicable; Formulated Product Glyphosate, N-(phosphonomethyl}glycine as the isopropylamine salt 41.0% 100.0% “Contains 480 grams per litre of the active ingredient isopropyiamine salt of N- (phosphanomethyljglycine Equivalent to 356 grams per litre of the acid, glyphosate, "*Contains approximately 15% v/v surfactant Not Applicable; Formulated Product JL IF SWALLOWED | REFORMULATION OR REPACKAGING ald 4. Health Effects Summary — the amount of information here varies greatly from one product to the next. But generally this section tells you how you can become exposed, it tells you how toxic the substance is to animals and it tells how it will affect your skin. The LD is a standard measure of toxicity and is a measure of the lethal dose required to kill 50% of a population of rats or some other research ani- mal. There are oral (given by mouth) and dermal (applied to the skin) LD’s. The lower the value the more toxic the pesticide is. OCCUPATIONAL CONTROL PROCEDURES Eye Protection: Wear chemical splash goggles during mixing/pouring operations or other activities in which eye contact with undiluted Vision® herbicide is likely to occur. Skin Protection: In cases in which prolonged or repeated skin contact with Vision herbicide may occur, long-sleeved shirt, long pants, and chemical protective (e.g. rubber) gloves are recommended. Wash hands and contaminated skin after handling. Clothing soaked with Vision solution should be promptly removed and laundered before reuse, Respiratory protection should not be required for normal use and handling. During periods of abnormal exposure to heavy spray or mist, use of U.S. NIOSH/MSHA approved equipment for pesticide vapor/mist is recommended. The respirator use limitations specified by NIOSH/MSHA or the manufacturer must be observed. Refer also to CSA Standard Z94.4-M1982, Selection, Care and Use of Respirators. Respiratory Protection: Ventilation: No special precautions are recommended Airborne Exposure Limits: (rellects U.S. statistics) Product: Vision Herbicide — 100% by wt. OSHA PEL: None established ACGIH TLV: None established Surfactant Ingredient: Approx. 15% by wt. OSHA PEL: None established ACGIH TLV: None established HEALTH EFFECTS SUMMARY The following information presents both human experience and the results of scientific experiments used by qualified experts to assess the effects of Vision herbicide on the health of exposed individuals and to support the precautionary statements and occupational control procedures recommended in this document. To avoid misunderstanding, the data provided in this section should be interpreted by individuals trained in evaluation of this type of information. Human Experience Dermal contact and inhalation are expected to be the primary routes of occupational exposure to Vision herbicide. Direct contact with this material may cause temporary eye irritation and conjunctivitis. Prolonged contact with Vision herbicide may cause dermal irritation. Ingestion of Vision herbicide has been reported to produce gastrointestinal discomfort, nausea, vomiting and diarrhea. Toxicological Data Data from Monsanto studies indicate the following: Oral LDs (Rat): Dermal LDs. (Rabbit): Eye Irritation (Rabbit, 24-hr): Skin Irritation (Rabbit, 24-hr): DOT Skin Irritation (Rabbit, 4-hr): Not Corrosive Inhalation LCsp (Rat, 4-hr) 3.18 mg/l (analytical concentration), Slightly Toxic Patch testing of 50 human volunteers with Vision herbicide at use concentration and 5X use concentration produced no positive reactions following initial application, any of 15 repeated applications in the induction phase, or on subsequent challenge 2 weeks later. Vision herbicide is not considered a primary irritant or a sensitizing agent. Patch testing of guinea pigs with Vision herbicide produced essentially no irritation following initial application; mild to moderate erythema (redness), edema (swelling) and/or mild necrosis (tissue damage) were observed in some animals during subsequent repeated exposures to the induction phase. ‘Onchallenge, no dermal response was observed in any of the animals. Vision herbicides not considered a dermal sensitizing agent in guinea pigs. Single male and female dogs were orally administered Vision herbicide or a2 percent aqueous solution of Vision herbicide at dosages ranging from 0.31250 5.0 mg/kg. No mortality and no inhibition of plasma acetyicholinesterase activity were reported. The most common effects observed were vomiting and diarrhea, which occurred shortly after dosing. A series of 21-day dermal toxicity studies have been conducted in which Vision herbicide was applied to the skin of male rabbits 6 hours per day, 5 days per week at various concentrations, At 5 times the intended use concentration, severe dermal irritation and systemic toxicity (mortality, reduced food consumption, body weight loss, and testicular effects) were observed. Rabbits treated with 3 times the intended use concentration and below, or only with the active ingredient glyphosate, exhibited only t to moderate local irritation and had no signs of systemic effects. When the surfactant in Vision formulation was tested, marked irritation and systemic effects were observed which were similarto those seen with the higher concentration of Vision. Effects observed in these studies are considered to be a secondary response to the stress of severe dermal irritation, to which rabbits are particularly sensitive, rather than the result of direct systemic toxicity. Rats were exposed by inhalation to aerosol concentration of 0.05, 0.16 and 0.36 mg of a 33.3% Vision solution perliter air 6 hours/day, 5 days/week fora total of 22 exposures over a4 week period. Minornasal irritation was observed in female animals. No adverse hematologic, biochemical or systemic histopathologic effects were noted. The systemic no-effect level was considered to be 0.36 mg of a33.3% Vision solution per liter of air. Following a 24-hr topical application of Vision herbicide to the abdomen of rhesus monkeys, approximately 1.8 of the administered dose of the active ingredient (glyphosate) was systemically absorbed. Excretion in the urine was the major route of elimination following systemic absorption. Components Data from Monsanto studies and from the scientific literature on the components of Vision herbicide is discussed below: Isopropylamine Salt of Glyphosate (MON 0139) Data from studies with a formulation comprised of 62% isopropylamine salt of glyphosate (MON 0139) indicate the following. (Please refer to the U.S. MON 0139 Material Safety Data Sheet 00010009. MON 0139 is not an item of commerce in Canada.) Solutions of MON 0139 (0.8% v/v and 4.0% v/v) were applied to the intact and abraded skin of rabbits at a dosage of 2 mg/kg for 6 hours/day, 5 days/week for 3 weeks. Irritation of the skin at the site of application was apparent at all dose levels tested. Repeated dermal application did not produce systemic effects as determined by hematology, clinical chemistry and histopathologic evaluations. Ina6-month oral toxicity study, beagle dogs were administered MON 0139 at dosages of 10, 60, and 300 mg/kg/day. Slightly reduced body weight gains and increased alkaline phosphatase activities were observed in high-dose males. No other changes in histopathological, ophthalmological, biochemical or clinical evaluations were noted. Giyphosate Glyphosate, the active herbicidal ingredient of VISION Herbicide, has been tested in mutagenicity, teratogenicity, reproductive, acute, subchronic and chronic toxicity studies. For toxicity information ‘on Glyphosate, refer to the Glyphosate Technical Material Safety Data Sheet. Surfactant 5,400 mg/kg, Practically Nontoxic >5,000 mg/kg, Practically Nontoxic (FHSA) Score = 4.1 on a scale of 110.0, Slightly Irritating (FHSA) Score = 4.3 on a scale of 8.0, Moderately Irritating The surfactant properties of this material are considered to contribute to the eye and skin irritation potential of Vision herbicide. LUMBERWORKER/APRIL, 1992/11